N'afọ ndị 1990, Pfizer butere ụzọ n'ịmepụta na depụta ngwaahịa shei capsule mbụ na-abụghị gellatin nke ụwa, isi akụrụngwa ya bụ cellulose ester "hydroxypropyl methyl cellulose" sitere na osisi.N'ihi na ụdị capsule ọhụrụ a enweghị ihe oriri anụmanụ, ụlọ ọrụ na-eto ya dị ka "capsule osisi".Ka ọ dị ugbu a, ọ bụ ezie na ọnụ ahịa ahịa nke capsules osisi n'ahịa capsule mba ụwa adịghị elu, mmepe mmepe ya siri ike nke ukwuu, yana ohere uto ahịa sara mbara.
　　
"Site na mmepe nke sayensị ọgwụ na nkà na ụzụ na sayensị ndị metụtara ya, mkpa nke ndị na-emepụta ọgwụ na-emepụta ọgwụ na-emepụta ọgwụ na-eji nwayọọ nwayọọ na-aghọta, na ọnọdụ nke ụlọ ahịa ọgwụ na-abawanye."Ouyang Jingfeng, onye na-eme nchọpụta na-arụkọ ọrụ na ụlọ akwụkwọ nkà mmụta sayensị nke Chinese Medical Sciences, kwuru na ọ bụghị nanị na ndị ọkachamara na-emepụta ọgwụ na-ekpebi àgwà nke ụdị usoro onunu ogwu ọhụrụ na nkwadebe ọhụrụ nke ọgwụ ruo n'ókè dị ukwuu, kamakwa na-enyere aka ịmepụta, kwụsie ike, solubilize. , mụbaa solubilize, ịgbatị ntọhapụ, ntọhapụ na-adịgide adịgide, ntọhapụ a na-achịkwa, nhazi oge, nhazi oge, ime ngwa ngwa, ịrụ ọrụ nke ọma na ogologo oge, na n'echiche, mmepe nke ihe ọhụrụ ọhụrụ excipient nwere ike iduga mmepe nke nnukwu klas. nke onunu ogwu iche-iche, melite àgwà nke a ọnụ ọgụgụ buru ibu nke ọhụrụ ọgwụ ọjọọ eme ihe na preparations, na mkpa ya karịrị nnọọ mmepe nke ọhụrụ ọgwụ.Na ọgwụ onunu ogwu ụdị dị ka ude ọgwụ, mbadamba, injections, na capsules, capsules aghọwo ndị bụ isi usoro onunu ogwu ụdị nke onu siri ike nkwadebe n'ihi na ha elu bioavailability, na-eme ka nkwụsi ike nke ọgwụ ọjọọ, na oge n'ọnọdu na ntọhapụ nke ọgwụ.

Ka ọ dị ugbu a, ihe bụ isi maka imepụta capsules bụ gelatin, gelatin na-eme site na hydrolysis nke ọkpụkpụ anụ na akpụkpọ anụ, yana macromolecule dị ndụ nke nwere usoro okirikiri ternary, nwere ezigbo biocompatibility na anụ ahụ na kemịkal.Agbanyeghị, capsules gelatin nwekwara oke ụfọdụ na ngwa, yana mmepe nke ihe ọhụrụ maka shells capsule nke na-abụghị anụmanụ abụrụla ebe na-ekpo ọkụ na nyocha na nso nso a nke ihe mgbakwunye ọgwụ.Wu Zhenghong, onye prọfesọ na mahadum China Pharmaceutical University, kwuru na n'ihi "ọrịa ehi ara" na mba Europe dịka britain, France na Netherlands na 1990s (gụnyere Japan na Eshia, nke hụkwara ehi ara nwere ọrịa ara) , ndị bi ná mba ndị dị n'Ebe Ọdịda Anyanwụ enweghị ntụkwasị obi siri ike maka ngwaahịa anụ ehi na anụ ụlọ (gelatin bụkwa otu n'ime ha).Na mgbakwunye, ndị Buddha na ndị anaghị eri anụ na-eguzogidekwa capsules gelatin nke sitere na akụrụngwa anụmanụ.N'ihi nke a, ụfọdụ ụlọ ọrụ capsule si mba ofesi malitere ịmụ ihe ọhụrụ maka shells capsule nke na-abụghị Gelatin na anụ anụmanụ ndị ọzọ, ikike nke capsules gelatin ọdịnala malitere ịka njọ.

Ịchọta ihe ọhụrụ iji kwadebe capsules na-abụghị gellatin bụ ntụziaka mmepe ugbu a nke ndị na-emepụta ọgwụ.Ouyang Jingfeng kwuru na akụrụngwa nke osisi capsules bụ ugbu a hydroxypropyl methylcellulose, starch gbanwetụrụ na ụfọdụ hydrophilic polymer food glues, dị ka gelatin, carrageenan, xanthan gum na na.Hydroxypropyl methyl cellulose capsules nwere yiri solubility, disintegration na bioavailability gelatin capsules, mgbe nwere ụfọdụ uru na gelatin capsules enweghị, ma ugbu a ngwa ka na-adịghị nnọọ ukwuu, tumadi n'ihi na elu price nke ngwaahịa, tụnyere gelatin. hydroxypropyl methyl cellulose capsule akụrụngwa akụrụngwa dị elu, na mgbakwunye na ngwa ngwa jel, na-ebute usoro mmepụta ogologo oge.

N'ahịa ọgwụ zuru ụwa ọnụ, capsules osisi bụ otu n'ime ngwaahịa na-eto ngwa ngwa.Wu Zhenghong kwuru na atụnyere gelatin capsules, osisi capsules nwere uru ndị a doro anya: Nke mbụ, enweghị mmeghachi omume na-agafe agafe.Capsules osisi nwere ike inertness siri ike na ọ dịghị mfe ịgafe otu aldehyde ma ọ bụ ogige ndị ọzọ.Nke abụọ dabara adaba maka ọgwụ na-emetụta mmiri.A na-achịkwa ihe dị n'ime mmiri nke capsules osisi n'etiti 5% na 8%, ọ dịghịkwa mfe iji kemịkal meghachi omume na ọdịnaya, na mmiri dị ala na-eme ka nkwụsi ike nke ọdịnaya hygroscopic nwere ike iru mmiri.Nke atọ bụ ezigbo ndakọrịta na isi ihe ndị na-emepụta ọgwụ.Capsules akwukwo nri nwere ezigbo ndakọrịta na lactose, dextrin, starch, microcrystalline cellulose, magnesium stearate na ihe ndị ọzọ a na-ejikarị ọgwụ eme ihe.Nke anọ bụ inwe ebe izu ike karịa.Capsules osisi nwere ihe ndị na-adịghị mma chọrọ maka ebe ọrụ nke ọdịnaya jupụtara, ma ọ bụ ihe ndị a chọrọ maka gburugburu ebe ọrụ ma ọ bụ ọnụego ngafe na igwe, nke nwere ike ibelata ọnụ ahịa eji.
　
　
"N'ụwa, osisi capsules ka na-eto eto, ọ bụ nanị ole na ole ụlọ ọrụ nwere ike na-emepụta osisi ọgwụ capsules, na ọ dị mkpa n'ihu ike nnyocha na mmepụta usoro na ndị ọzọ akụkụ, na-amụba ahịa nkwalite mgbalị."Ouyang Jingfeng mere ka ọ pụta ìhè na ugbu a, mmepụta nke gelatin capsules na China erutela ebe mbụ n'ụwa, ebe ahịa ahịa nke ngwaahịa capsule osisi ka dị ala.Tụkwasị na nke ahụ, n'ihi na ụkpụrụ nke ịmepụta capsules agbanwebeghị maka ihe karịrị otu narị afọ, na-emeziwanye akụrụngwa na-aga n'ihu dị ka usoro mmepụta nke gelatin si dị, otu esi eji usoro na ngwá ọrụ maka ịkwadebe gelatin capsules iji kwadebe osisi. capsules aghọwo a na-elekwasị anya nke nnyocha, nke na-agụnye kpọmkwem ọmụmụ nke usoro ihe dị ka viscosity, rheological Njirimara na viscoelasticity nke ihe.
　　

Ọ bụ ezie na ọ gaghị ekwe omume ka capsules osisi dochie anya ọchịchị nke gelatin oghere capsules, osisi capsules nwere uru asọmpi doro anya na nkwadebe ọgwụ ndị China ọdịnala nke China, nkwadebe ndu na nri na-arụ ọrụ.Zhang Youde, onye isi injinia na School of Materials Science and Engineering of Beijing Institute of Technology, kwenyere na site na nghọta miri emi nke ndị mmadụ banyere capsules osisi na mgbanwe nke echiche ọgwụ ọha na eze, ọchịchọ ahịa maka capsules osisi ga-eto ngwa ngwa.